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激肽-激肽释放酶系统在心血管疾病发展中的重要作用
作者:杨帆1  姚玉宇1  马根山2 
单位:1. 东南大学医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 心内科, 江苏 南京 210009
关键词:激肽 缓激肽 激肽释放酶 心血管病 
分类号:R541
出版年·卷·期(页码):2013·32·第五期(612-617)
摘要:

激肽-激肽释放酶系统(KKS)是一个复杂的内源性多酶系统。激肽在血管内皮与缓激肽受体结合,从而触发瀑布式的生物效应,其效应包括血管舒张、平滑肌收缩舒张,抑制细胞凋亡、细胞炎症、细胞肥大、细胞纤维化以及促进血管生成和神经发生等。在心脑血管系统的多种病理生理进程中,激肽-激肽释放酶系统扮演了重要的角色。作者对KKS的作用机制及其在高血压、心力衰竭、左室肥厚、心肌缺血、心肌病、脑卒中等发展中的作用作一综述。

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