糖尿病视网膜病变(DR)是代谢综合征所致的严重微血管病变之一,也是该类患者致盲的重要原因。目前提出高瘦素(leptin)、低脂联素(adiponectin)血症、高胰岛素原血症等均可能为代谢综合征的组成部分。越来越多的证据发现,瘦素是一种新生血管因子,其在玻璃体中的水平与新生血管性眼病相关。这也被认为是其参与糖尿病视网膜病变发生发展的因子之一,但其对于糖尿病视网膜病变中的氧化损伤及在糖尿病视网膜病变亚临床期及非增殖期中的作用仍尚待阐明。本文综述近年瘦素在糖尿病视网膜病变中的作用的研究进展。

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