重症急性胰腺炎(severe acute pancreatitis,SAP)病程中产生大量的包括细胞因子在内的炎性介质,机体出现全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)从而导致多脏器损伤。TNF-α、IL-1、IL-6、IL-8、IL-18、MIF(macrophage migration inhibitory)以及NF-κB等引起肺、肝、肾、脑的损伤的机制复杂;各种针对细胞因子的治疗能有效地改善SAP患者的病情。作者就SAP时细胞因子对多器官损伤影响的研究进展作一综述。

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