β-半乳糖凝集素-3与上皮钙黏蛋白在甲状腺乳头状癌组织中的表达及其意义-东南大学学报医学版

β-半乳糖凝集素-3与上皮钙黏蛋白在甲状腺乳头状癌组织中的表达及其意义

单位：江苏省肿瘤医院

分类号：

出版年·卷·期（页码）：2011·30·第四期（598-602）

摘要：

目的：检测β-半乳糖凝集素-3（Galectin-3）和上皮钙粘蛋白（E-cadherin）在甲状腺乳头状癌（PTC）组织中的表达，筛选甲状腺乳头状癌的辅助诊断指标及预测淋巴结转移及包膜侵犯的可能性。方法：采用组织芯片免疫组化法检测结节性甲状腺肿伴乳头状增生10例，10例甲状腺腺瘤，5例正常甲状腺组织，甲状腺乳头状癌236例（无淋巴结转移190例，有淋巴结转移46例；有包膜侵犯159例，无包膜侵犯77例）中β-半乳糖凝集素-3和上皮钙粘蛋白的表达。结果：1. β-半乳糖凝集素-3表达以甲状腺乳头状癌有淋巴结转移最强，分别为99.47%，无淋巴结转移较56.52 %，甲状腺乳头状增生更低30.0 %，3组有显著差异（P<0.05）。E-Cadherin表达以甲状腺乳头状增生最强80.0%，甲状腺乳头状癌无淋巴结转移8.70%，有淋巴结转移更低20.53%，3组间有显著差异（P<0.05）。2. β-半乳糖凝集素-3表达以甲状腺乳头状癌有包膜外侵犯最强，分别为95.90%，无包膜外侵犯95.61%，无明显差异（P>0.05）。甲状腺乳头状增生较低30.0%。E-Cadherin表达以甲状腺乳头状增生80.0%，甲状腺乳头状癌无包膜外侵犯9.65%，有包膜外侵犯23.77%，3组间有显著差异（P<0.01）。3. 根据两种蛋白表达阳性率行统计学分析，结果显示两种蛋白表达强度相互之间无相关性。结论：1. Galectin-3、E-cadherin联合检测有望作为预测淋巴结转移及包膜外侵犯的参考指标。2. Galectin-3蛋白阳性表达阳性率在甲状腺乳头状癌伴淋巴结转移组高于无淋巴结转移者。E-cadherin蛋白在有甲状腺乳头状癌腺体外侵犯及淋巴结转移病例表达低于无腺体外侵犯及淋巴结转移病例，可联合测定Galectin-3、E-cadherin蛋白表达判定有无腺体外侵犯及淋巴结转移。

Objective:To examine the expression of Galectin-3 and E-cadherin in the thyroid papillary carcinoma so as to screen the auxiliary diagnostic index and to predict the possibility of the transferring into lymph node and invasion of envelope. Methods:Immunohistochemical SP method was used to examine the expression of Galectin-3 and E-cadherin in 10 goiter with papillary hyperplasia、10 thyroid adenoma、5 normal thyroid tissue and 236 thyroid papillary carcinoma in which 190 had lymph node transferring and 46 had not, 159 had invasion of envelope and 77 had not. Results: 1. The expression of Galectin-3 in the thyroid papillary carcinoma with lymph node transferring is the highest 99.47% , low in the thyroid papillary carcinoma without lymph node transferring 56.52% and the lowest in the thyroid papillary hyperplasia 30.0% . The difference was significant (P<0.05) ;The expression of E-Cadherin is the highest in the thyroid papillary hyperplasia 80.0% , low in the thyroid papillary carcinoma without lymph node transferring 8.7 % and the lowest in the thyroid papillary carcinoma with lymph node transferring 20.53% . The difference is significant (P<0.05) 2. The expression of Galectin-3 in the thyroid papillary carcinoma with invasion of envelope is the highest 95.90% , low in the thyroid papillary carcinoma without invasion of envelope 95.61% and the lowest in the thyroid papillary hyperplasia 30.0% . The difference was significant (P>0.05) ;The expression of E-Cadherin is the highest in the thyroid papillary hyperplasia 80.0% , low in the thyroid papillary carcinoma without invasion of envelope 9.65% and the lowest in the thyroid papillary carcinoma with invasion of envelope 23.77%. The difference is significant (P<0.05). 3. According to the statistics,there is no significant difference between the expression of the two kinds of proteins. Conclusion :1. In the tissues of papillary carcinoma of thyroids, the expression ratio of Galectin-3 increased while that of E-ca

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