Objective To explore the correlation and its significance of Glycated Albumin(GA) and Monocyte Chemoattractant Protein-1(MCP-1) in the peripheral blood of patients with Acute Cronary Syndrome(ACS). Methods The peripheral blood concentrations of GA and MCP-1 were measured in forty-six patients with ACS (ACS group), thirty-two patients with Stable Angina pectoris (SAP group) and thirty patients with Control subjects (Control group) by NBT Color and enzyme-linked immunosorbent assay (ELISA). The aspects of coronary artery lesions were analyzed. Results Circulating GA and MCP-1 levels were significantly higher in patients with ACS than in patients with stable angina and controls (P<0.01); the levels of GA or MCP-1 in peripheral blood was not correlated with culprit coronary artery lesions in ACS and SAP groups (P>0.05). GA level was positively correlated with MCP-1 level in Acute Coronary syndrome (ACS) (r=0.501, P<0.01).Conclution The leves of GA and MCP-1 in peripheral blood may be two useful makers reflecting the unstable of the disease, but the levels of GA or MCP-1 have no correlation with the degree of coronary artery lesions in ACS and SAP groups. And there are intrinsic correlation between the levels of GA or MCP-1 in peripheral blood, which implicates that the interaction of factors may faclitate the development of Acute Coronary Syndrome (ACS). |