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急性冠脉综合征患者外周血清糖化白蛋白和单核细胞趋化蛋白水平变化的临床意义
作者:张丽 冯毅 马根山 
单位:东南大学附属第二医院
关键词: 急性冠脉综合征 糖化白蛋白 单核细胞化学吸引蛋白质1 
分类号:
出版年·卷·期(页码):2011·30·第二期(324-327)
摘要:

目的 探讨急性冠脉综合征患者外周血糖化白蛋白(GA)、单核/巨噬细胞趋化蛋白1(MCP-1)水平的变化与ACS发生发展的关系。方法 使用硝基四氮唑兰(NBT)显色法和酶联免疫吸附法分别测定46例急性冠脉综合征患者(急性冠脉综合征组),32例稳定型心绞痛患者(稳定型心绞痛组)及30例胸痛、胸闷等症状予以冠脉造影正常的患者(对照组)血中GA和MCP-1水平的变化,并分析冠状动脉的病变情况。结果 血GA、MCP-1水平在ACS患者明显高于SAP及对照组(P<0.01);急性冠脉综合征组和稳定型心绞痛组冠状动脉狭窄程度积分与外周血GA和MCP-1水平均无明显相关性(P>0.05);急性冠脉综合征组外周血GA和MCP-1水平呈明显相关性(r=0.501,P<0.01)。结论 外周血GA、MCP-1水平可能预测急性冠脉综合征发生的危险性,但与冠状动脉的病变程度无明显关系,GA和MCP-1的正相关提示因子在冠脉综合征的发生和发展中有重要作用。

Objective To explore the correlation and its significance of Glycated Albumin(GA) and Monocyte Chemoattractant Protein-1(MCP-1) in the peripheral blood of patients with Acute Cronary Syndrome(ACS). Methods The peripheral blood concentrations of GA and MCP-1 were measured in forty-six patients with ACS (ACS group), thirty-two patients with Stable Angina pectoris (SAP group) and thirty patients with Control subjects (Control group) by NBT Color and enzyme-linked immunosorbent assay (ELISA). The aspects of coronary artery lesions were analyzed. Results Circulating GA and MCP-1 levels were significantly higher in patients with ACS than in patients with stable angina and controls (P<0.01); the levels of GA or MCP-1 in peripheral blood was not correlated with culprit coronary artery lesions in ACS and SAP groups (P>0.05). GA level was positively correlated with MCP-1 level in Acute Coronary syndrome (ACS) (r=0.501, P<0.01).Conclution The leves of GA and MCP-1 in peripheral blood may be two useful makers reflecting the unstable of the disease, but the levels of GA or MCP-1 have no correlation with the degree of coronary artery lesions in ACS and SAP groups. And there are intrinsic correlation between the levels of GA or MCP-1 in peripheral blood, which implicates that the interaction of factors may faclitate the development of Acute Coronary Syndrome (ACS).

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